Apnea is associated with neurodevelopmental impairment in very low birth weight infants.Factors influencing apnea and bradycardia of prematurity—implications for neurodevelopment.The effect of gestational age on the incidence and duration of recurrent apnoea in newborn babies.Margin of safety for discharge after apnea in preterm infants.Inter-neonatal intensive care unit variation in discharge timing: influence of apnea and feeding management.Variation in diagnosis of apnea in moderately preterm infants predicts length of stay.Epidemiology and predictors of failure of the infant car seat challenge.Apnea frequently persists beyond term gestation in infants delivered at 24 to 28 weeks.Under-recognition of alarms in a neonatal intensive care unit.Collaborative Home Infant Monitoring Evaluation (CHIME) Study GroupCardiorespiratory events recorded on home monitors: comparison of healthy infants with those at increased risk for SIDS.Effects of caffeine on intermittent hypoxia in infants born prematurely: a randomized clinical trial.Prematurity and sudden infant death syndrome: United States 2005-2007.Committee on Fetus and Newborn, American Academy of PediatricsApnea, sudden infant death syndrome, and home monitoring.Genetic basis of apnoea of prematurity and caffeine treatment response: role of adenosine receptor polymorphisms.Heritability of apnea of prematurity: a retrospective twin study.Long-term effects of caffeine therapy for apnea of prematurity.Caffeine for Apnea of Prematurity (CAP) Trial InvestigatorsSurvival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity.Timing of caffeine therapy in very low birth weight infants.Caffeine for Apnea of Prematurity Trial: benefits may vary in subgroups.Trends in caffeine use and association between clinical outcomes and timing of therapy in very low birth weight infants.Continuous positive airway pressure selectively reduces obstructive apnea in preterm infants.Randomised crossover trial of four nasal respiratory support systems for apnoea of prematurity in very low birthweight infants.Effects of transfusions in extremely low birth weight infants: a retrospective study.Blood transfusion in anemic infants with apnea of prematurity.Anemia, apnea of prematurity, and blood transfusions.Gastroesophageal reflux and apnea of prematurity: no temporal relationship.Gastroesophageal reflux and apnea of prematurity—coincidence, not causation[commentary on Corvaglia L et al.
doi: 10.7554/eLife.45399.J Mol Cell Cardiol. It generally resolves by 36 to 37 weeks’ PMA in infants born at ≥28 weeks’ gestation.Infants born at <28 weeks’ gestation may have apnea that persists to or beyond term gestation.Individual NICUs are encouraged to develop policies for cardiorespiratory monitoring for infants considered at risk of apnea of prematurity.Initial low heart rate alarms are most commonly set at 100 beats per minute. Any conflicts have been resolved through a process approved by the Board of Directors.
Epub 2016 Jun 7.
2018 Jan;114:58-71. doi: 10.1016/j.yjmcc.2017.10.004.
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Clipboard, Search History, and several other advanced features are temporarily unavailable. Healthy infants who have had apnea of prematurity usually do not go on to have more health or developmental problems than other babies. 34.
apnea of prematurity does not cause brain damage, and a healthy baby who is apnea free for a week will probably never have apnea of prematurity again.
In practice, many apneic events in preterm infants are shorter than 20 seconds, because briefer pauses in airflow may result in bradycardia or hypoxemia.
2017 Mar 1;595(5):1637-1655. doi: 10.1113/JP273471. Despite the frequency of apnea of prematurity, it is unknown whether recurrent apnea, bradycardia, and hypoxemia in preterm infants are harmful. Author information: (1)Department of Paediatric Pulmonology, Medizinische Hochschule, Hannover, FRG. Apnea of Prematurity powerpoint 1. 1992 Nov;81(11):875-80. doi: 10.1111/j.1651-2227.1992.tb12127.x.Poets CF, Stebbens VA, Alexander JR, Arrowsmith WA, Salfield SA, Southall DP.Arch Dis Child. Additional close monitoring in these situations may be indicated in preterm infants until 44 weeks’ PMA, including former preterm infants readmitted for elective surgical procedures, such as hernia repair.
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