What these trials have established is the safe and effective anticancer dose of albendazole.
Purpose: Angiogenesis and vessel hyperpermeability are the two factors leading to the formation of ascites. The reason is simple; the anti-cancer dose of albendazole and duration of therapy is prolonged in comparison to its use as an antiparasitic agent. High-grade serous ovarian carcinoma (HGSOC) is the most aggressive subtype of ovarian cancer. They may also have a different safety profile. These drugs have been in widespread use in medicine since the 1970s, with proven safety record in humans. The female reproductive system contains two ovaries, one on each side of the uterus. They have found that a group of medications used to treat parasitic diseases or helminthic manifestations can, in fact, help cancer patients.Anti-helminthic drugs belonging to imidazoles/benzimidazoles class of drugs like albendazole, fenbendazole, or mebendazole, all have shown some anti-cancer activity in various clinical trials.There are numerous reasons for the interest in these medications. They are not probable to be used as a monotherapy, instead, in combination with other well-known drugs.
Not to mention that taking drugs is more accessible than surgery or radiotherapy.However, everyone knows the numerous side effects that come with traditional chemotherapy.
The ovaries — each about the size of an almond — produce eggs (ova) as well as the hormones estrogen and progesterone.Ovarian cancer often goes undetected until it has spread within the pelvis and abdomen. The effectiveness of anti-cancer drugs in treating HGSOC is significantly reduced due to p53 mutations, which are found in most HGSOC (96%) tumors. It was a phase one study with a primary focus on drug safety. In practice, it means that apart from killing cancer cells by inhibiting the formation of microtubules (vital protein), albendazole may prevent the formation of new blood vessels in tumors and thus promoting their shrinkage.These trials are still in the early stages. Out of these 24 patients, four of them showed better results than others with tumor markers falling more than 50% from baseline after treatment with albendazole.Further, all patients demonstrated change/reduction in VEGF concentrations.
Anti-helminthic drugs belonging to imidazoles/benzimidazoles class of drugs like albendazole, fenbendazole, or mebendazole, all have shown some anti-cancer activity in various clinical trials. Thus, they severely interrupt the energy supply to cancer cells. These studies have also shown various mechanisms of action of the drug.
We have recently shown that albendazole inhibits peritoneal growth of human colorectal cancer cells (HT-29).
The cost of chemotherapy also remains a barrier to treating cancer.Wouldn’t it be great if some commonly used, cheaply available drug with established safety records could help treat cancer?It seems that drugs commonly used to kill or expel parasitic worms from the body may have anticancer properties.Modern researchers have identified anti-cancer properties in many medicines used to treat other medical conditions. When combined with other chemotherapy drugs, they not only increase their effectiveness but also prevent the development of resistance to these drugs.These medications may have a role in the treatment of breast, small cell lung, hepatic, head and neck, bile duct, and many other types of cancers.A recent study demonstrated the safety and efficacy of albendazole in the treatment of cancer. The repurposed drug mebendazole (MBZ) is effective against cancer cells at lower doses. Standard treatment options have a poor survival rate given high risk of recurrence with chemoresistant disease. Mebendazole is a (synthetic) broad-spectrum anthelmintic available as chewable tablets, each containing 100 mg of Mebendazole.
Although, samples taken later demonstrated huge variations.
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