Dutasteride is also used off-label in the treatment of female pattern hair loss. The two drugs in this class that are available in the U.S. are finasteride (brand names: Proscar® and Propecia®) and dutatsteride (Avodart®).Finasteride and dutasteride are both in the same class of drug, but there is a distinct difference between the two. J Urol, 2008 Jun;179(6):2333-8.18.

Best Pract Res Clin Endocrinol Metab, 2008 Apr;22(2):223-8.3. Dutasteride can help improve urine flow. Show Printable Version; Email this Page… Rate This Thread. Montorsi F, Alcaraz A, et al. Prague Med Rep, 2009;110(3):222-30. Interestingly, a study of female-to-male transsexuals treated with a long-acting testosterone and dutasteride observed an effect suggesting the addition of dutasteride resulted in a failure to gain lean mass (muscle).19 Conversely, a rat study demonstrated that the anabolic effect of supraphysiologic testosterone is maintained during 5aRI use.20 J Sex Med, 2008 Oct;5(10):2442-53.20. Version: 11.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The consequences of an elevated androgenic signal are difficult to differentiate from individual variation and not associated with known consequence during an adult male's young- and mid-adult years. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Front Neuroendocrinol, 2008 May;29(2):169-81.7. This suggests that the brain raised the threshold concentration for testosterone (DHT/estradiol) before it would shut down production.

The enzyme 5 alpha-reductase exists in two forms, type 1 and type 2.7,11 Finasteride, the original 5aRI, inhibits only type 2. Zhu YS, Imperato-McGinley JL. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle dutasteride capsules.Using dutasteride may increase your risk of developing Dutasteride is not for use by women, and this medicine can cause birth defects if a woman is exposed to it during pregnancy. Excessive hair growth. However, this balance is fairly delicate, as excesses either way (androgenic or estrogenic) can cause adverse changes to one's health and appearance. Dutasteride may also be used for purposes not listed in this medication guide.Dutasteride can cause birth defects if a woman is exposed to it during pregnancy. J Urol, 2008 Apr;179(4):1235-42.12. Though promoted as being capable of providing the effects of oral anabolic steroids, these products generally failed to deliver; some even elevated estrogen levels.1 A few of the prohormones did provide an anabolic effect, though many (including the FDA) challenged that these products were in fact drugs, rather than a nutrition-based ingredient.Metabolically, testosterone is both a hormone and a prohormone. Testosterone, and its androgenic metabolite DHT, induce a number of cellular responses in the human body; nearly two thousand genes are known to be responsive to receptor-bound testosterone/DHT.5 It is worth mentioning that most of the effects of androgens (i.e., testosterone, DHT, most anabolic steroids) are due to hormones stimulating genes (DNA) to respond to a growth signal. Clinically, dutasteride has shown itself to be more effective than finasteride.11 At this point, most readers are likely wondering how this relates to building muscle.Natural testosterone production is regulated by slowing hormone production as concentrations rise in the blood. It’s worth noting that dutasteride has not received FDA approval as a treatment for male pattern baldness. Call your doctor for medical advice about side effects. Scott MJ 3rd, Scott AM. Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase. Taurus. Combined inhibition of types I and II 5 alpha-reductase selectively augments the basal (nonpulsatile) mode of testosterone secretion in young men. Non-genomic actions of androgens. Talih F, Fattal O, et al. When estrogen levels are elevated, signs of the imbalance become evident through certain feminizing effects, such as the growth of breast tissue under the male's nipple(s). Expert Opin Drug Saf, 2008 Nov;7(6):691-702.5.

Andriole GL, Kirby R. Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia. Dutasteride is a medication used for the treatment of benign prostatic hyperplasia also known as an enlarged prostate.Dutasteride belongs to a class of medication called 5-alpa reductase inhibitors.

Although no reports specific to dutasteride currently exist, 5α-reductase inhibitors like finasteride have been found to be effective in the treatment of hirsutism (excessive facial and/or body hair growth) in …

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