This is a chronic, slowly-progressing condition. Worsening of hypertension was reported infrequently in Myrbetriq clinical trial patients with OAB.In patients taking Myrbetriq, urinary retention has been reported in patients with bladder outlet obstruction (BOO) and in patients taking antimuscarinic medications for the treatment of OAB.
Cases of angioedema have been reported to occur hours after the first dose or after multiple doses. If involvement of the tongue, hypopharynx, or larynx occurs, promptly discontinue Myrbetriq and/or solifenacin succinate and initiate appropriate therapy and/or measures necessary to ensure a patent airway.Solifenacin succinate should be administered with caution to patients with decreased gastrointestinal motility, controlled narrow-angle glaucoma or reduced renal or hepatic function.


This class of medication can affect eye pressure in people that have open-angle glaucoma, but can also raise eye pressure in those with the angle-closure form of the disease. Drug interaction studies were conducted to investigate the effect of co-administered drugs on the pharmacokinetics of mirabegron and the effect of mirabegron on the pharmacokinetics of co‑administered drugs. Use of solifenacin succinate in patients with severe hepatic impairment is not recommended.Anticholinergic central nervous system (CNS) effects have been reported with solifenacin succinate use, including headache, confusion, hallucinations and somnolence. Carbidopa-levodopa products are contraindicated in patients with narrow-angle glaucoma.

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Angle-closure glaucoma, the second most common type, is a largely inherited disorder caused by a too-narrow angle in the passageway where aqueous fluid would normally drain.This type of glaucoma may occur in two ways: The chronic type progresses slowly and, like open-angle glaucoma, can result in optic nerve damage. Use of solifenacin succinate in patients with severe hepatic impairment is not recommended.Anticholinergic central nervous system (CNS) effects have been reported with solifenacin succinate use, including headache, confusion, hallucinations and somnolence. This article explores the classes of medications that may affect the open-angle and angle-closure forms of glaucoma. Periodic blood pressure determinations are recommended, especially in hypertensive patients. Other side effects in the eye, beyond increased pressure, include cataracts.Not every person develops elevated eye pressures when taking oral steroids. Most medications that could adversely affect glaucoma, or increase the chance of developing glaucoma, have the potential to narrow the drainage angle of your eye, called the Therefore, if you have a known history of narrow angles or the condition known as angle-closure glaucoma, you should definitely call your ophthalmologist prior to using any medication that has a glaucoma warning.Medications that have anticholinergic properties can adversely affect patients with narrow angles.

Cases of angioedema have been reported to occur hours after the first dose or after multiple doses. The information contained on Astellas Medical Information is intended for U.S. healthcare professionals only.This website is funded and developed by Astellas Pharma US, Inc. Myrbetriq is a registered trademark of Astellas Pharma Inc.I further certify that my participation in this program is consistent with all applicable state laws and any obligations, contractual or otherwise, that I have as a pharmacy provider. And, of course, topical steroid eye drops can increase eye pressure, but if you are using these medications, you should already be under the care of an eye care provider.There are many other medications than can increase the risk of glaucoma in addition to the ones mentioned in this article, so it is always wise to talk with your pharmacist or your eye doctor about your medication regimen.

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